For any aspiring writer, a rejection letter, regardless of the provenience of said letter, is one of the most dreaded of objects. In this line of work getting rejected is considered a sort of literary murder - people are knowingly destroying something you've spent time on, and a lot of it. But the thing is everyone got rejected, more or less.
Read this interesting post over at Cristian Mihai's blog. Isn't it nice that indie publishing is changing the "playing field" in a big way now, when it comes to publishers holding so/too much power! Now, agents are trolling Amazon's Kindle store for authors, on a regular basis. Talk about a 360! ;<)